Cov khoom
2,4-Diamino-6-hydroxypyrimidine
Hydroxypyrimidine Chemical Properties
| Melting point | 285-286 ° C (Lub Kaum Ob Hlis) (lit.) |
| Boiling point | 234.22°C (kev kwv yees) |
| ceev | 1.3659 (kev kwv yees kwv yees) |
| Refractive Index | 1.7990 (kwv yees) |
| cia temp. | Khaws nyob rau hauv qhov chaw tsaus, inert cua, chav tsev kub |
| solubility | DMSO (me ntsis), Methanol (me ntsis) |
| pka ua | 10.61 ± 0.50 (Tshaj tawm) |
| daim ntawv | Fine Crystalline hmoov |
| xim | Dawb rau cream |
| rhiab heev | Lub teeb Sensitive |
| Merck | 14 Ib., 2981 |
| BRN | 12 5006 |
| InChIKey | SWELIMKTDYHAOY-UHFFFAOYSA-N |
| CAS DataBase Reference | 56-06-4 (CAS DataBase Reference) |
| NIST Chemistry Reference | 4(1H)-pyrimidinone, 2,6-diamino-(56-06-4) |
| EPA Tshuaj Registry System | 2,6-Diamino-4(1H)-pyrimidinone (56-06-4) |
Hydroxypyrimidine Product Description
2,4-Diamino-6-hydroxypyrimidine yog cov tshuaj sib xyaw nrog cov mis molecular C4H6N4O.Nws yog ib qho organic compound teej tug mus rau tsev neeg pyrimidine.Cov compound muaj ib lub nplhaib pyrimidine, ob pawg amino (NH2) txuas nrog ntawm 2-txoj hauj lwm thiab 4-txoj hauj lwm, thiab ib pawg hydroxyl (OH) txuas ntawm 6-txoj hauj lwm.Cov qauv tshuaj muaj peev xwm qhia tau tias: Ammonia ||H--C--C--C--N--C--C--NH2 ||oh 2,4-Diamino-6-hydroxypyrimidine muaj ntau yam kev siv hauv kev lag luam kws tshuaj.Nws yog ib qho tseem ceeb nruab nrab hauv kev sib xyaw ntawm ntau cov tshuaj, suav nrog tshuaj tua kab mob thiab tshuaj tua kab mob.Nws kuj tseem siv los tsim ntau yam nucleotide analogs siv hauv kev tshawb fawb tshuaj.
Ntxiv nrog rau kev siv tshuaj, 2,4-diamino-6-hydroxypyrimidine kuj tseem siv los ua cov khoom xyaw hauv agrochemicals.Nws yog ib qho tseem ceeb muaj nyob rau hauv lub synthesis ntawm cov nroj tsuag kev loj hlob regulators thiab fungicides.Nws yog ib qho tseem ceeb heev uas yuav tsum ua raws li txoj cai kev nyab xeeb kom raug thaum siv 2,4-diamino-6-hydroxypyrimidine.Txij li thaum nws raug cais raws li cov tshuaj lom neeg, nws yuav tsum tau saib xyuas thiab siv cov cuab yeej tiv thaiv tus kheej kom tsim nyog kom tsis txhob muaj kev sib cuag ncaj qha.
Hauv cov ntsiab lus, 2,4-diamino-6-hydroxypyrimidine yog ib qho organic compound nrog kev siv hauv kev lag luam thiab kev ua liaj ua teb.Nws cov qauv tshuaj ua rau nws muaj txiaj ntsig zoo li qhov nruab nrab hauv kev sib xyaw ntawm cov tshuaj thiab cov nroj tsuag kev loj hlob regulators.
Cov ntaub ntawv kev nyab xeeb
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 ib |
| Cov lus hais txog kev nyab xeeb | 22-24/25-36-26 ib |
| WGK Germany | 3 |
| Kev Ceeb Toom | Irritant |
| TSCA | Yog lawm |
| HS Code | 2933595 ib |
Kev siv Hydroxypyrimidine thiab Synthesis
| Kev piav qhia | 2,4-Diamino-6-hydroxypyrimidine (DAHP) yog ib qho kev xaiv, tshwj xeeb inhibitor ntawm GTP cyclohydrolase I, tus nqi txwv cov kauj ruam rau de novo pterin synthesis.Hauv HUVEC hlwb, IC50rau inhibition ntawm BH4biosynthesis yog kwv yees li 0.3 mM.DAHP tuaj yeem siv los thaiv tsis muaj ntau lawm hauv ntau hom cell. |
| Chemical Properties | Dawb Khoom |
| Siv | 2,4-Diamino-6-hydroxypyrimidine (DAHP) yog ib qho kev xaiv, tshwj xeeb inhibitor ntawm GTP cyclohydrolase I, tus nqi txwv cov kauj ruam rau de novo pterin synthesis.Hauv HUVEC hlwb, IC50 rau inhibition ntawm BH4 biosynthesis yog li 0.3 mM.DAHP tuaj yeem siv los thaiv tsis muaj ntau lawm hauv ntau hom cell.[Cayman Chemical] |
| Siv | Nws sawv ntawm qhov pib ntawm enzyme-catalyzed cascade uas pib nrog xya-carbon carbohydrate thiab xaus nrog cov amino acids uas muaj ntxhiab phenylalanine, tyrosine, thiab tryptophan. |
| Siv | 2,4-Diamino-6-hydroxypyrimidine (cas # 56-06-4) yog ib qho khoom siv hauv cov organic synthesis. |
| Txoj kev Purification | Nws recrystallises los ntawm H2O.[Beilstein 25 III/IV 3642.] |
