Khoom
Di-tert-butyl dicarbonate; CAS Tsis muaj: 24424-99-5
Txhais lus hais tias: BIS (TERT-BUTOXCARBYL) Oxide; Boc Street; Di-Trickarbonate; di-tert-butylandicarbonate
Cov Khoom Muaj Tshuaj Ntawm Di-Tert-Butyl Dicarbonate
Winds Ntag / Xim: Dawb rau off-dawb microcrystalline hmoov
Art Vapor Siab: 0.7mmHg ntawm 25 ° C
● Melting point: 22-24 ° C
● Cov ntsiab lus tsis zoo: 1.4090
● Bo Bowing taw tes: 235,8 ° C ntawm 760 MMHG
Flash taw tes: 103.7 ° C
● Psa:61.83000
Wensity: 1.054 g / cm3
● Cov cim: 2.87320
● Cov temp.:2-882882
● Rhiab .:Moisture rhiab
● Dej Solubility.:Miscible nrog decalin, carbon tetrachloride, tetrahydrofuran, Dioxane, tshuaj txhoj, acetone, acetone, acetone thiab dimethylform
● XlogP3: 2.7
It Hydrogen BRonor pub nyiaj: 0
Hydrogen BRRongle Txais Txais Suav: 5
Resot Rotatable Bond COUNTER: 6
● Muaj tseeb tseeb: 218.11542367
● Hnyav Hom Dav: 15
● Cov lus tsis zoo: 218
Cov Ntaub Ntawv Safty
● POTOSSGRAM (S):
T, T +,
F, f +,
Xi
● Cov kab mob txaus ntshai: T +, T, F, Xi, F +
Cov nqe lus: 11-19-26 / 37 / 38-43-10-43
● Cov nqe lus muaj kev nyab xeeb: 16-26-26-26 / 37-45-7 / 9-37 / 39-24 / 37 / 39-33
Zoo siv
Tshuaj lom neeg:Lwm cov chav kawm -> Esters, lwm yam
Canonical luag nyav:Cc (c) (c) OC (= O) OC (= O) OC (c) (C) C
Siv:Di-tert-butyl dicarbonate (boc2o) yog siv reagent siv dav rau kev qhia kev tiv thaiv pab pawg hauv cov hluavtaws hauv peptide. Nws ua lub luag haujlwm tseem ceeb hauv kev npaj ntawm 6-acetyl-1,2,4-tetraydropyridine los ntawm reacting nrog 2-piperidone. Nws pabcuam ua kev tiv thaiv pab pawg siv hauv theem khoom peptide synthesis.
Cov lus qhia ntxaws ntxaws
Di-Tert-Butyl Dicarbonateyog reagent siv nyob rau hauv cov etthic synthesis. Nws tseem muaj lub npe hu ua T-boc anhydride lossis boc anhydride. Nws yog ib feem siv los tiv thaiv amine ua haujlwm rau lub sijhawm tshuaj lom neeg. Di-tert-butyl dicarbonate reacts nrog amines los ua daim ntawv derivatives, muab kev tiv thaiv ib ntus rau cov amine pawg. Thaum cov tshuaj tiv thaiv tau ua tiav, cov pab pawg carbamate tuaj yeem tshem tawm yooj yim los ntawm kev kho nrog kua qaub, yielding tus thawj amine ua haujlwm. Qhov no yog qhov muaj txiaj ntsig zoo rau kev hloov kho qee pab pawg ua haujlwm hauv cov organic molecules.
Daim ntawv thov
Ntxiv nrog rau kev tiv thaiv amine pab pawg, di-tert-butyl dicarbonate muaj ntau lwm cov ntawv thov hauv synthesis:
Kev tiv thaiv ntawm hydroxyl pawg:Di-tert-butyl dicarbonate tuaj yeem ua kom muaj kev haus cawv kom muaj cov pa roj carbonates, tiv thaiv pab pawg hydroxyl. Cov pab pawg carbonate tuaj yeem muab tshem tawm cov kev mob uas tsim nyog, tso cai rau kev xaiv kev hloov kho ntawm lwm pab pawg ua haujlwm.
CarbonicLation tshua muaj:Di-tert-butyl dicarbonate tuaj yeem siv los ua ib qho chaw ntawm cov pa roj carbon monoxide hauv carbonyLation tshua. Nws reacts nrog nucleophiles xws li amines, cawv, thiab thiols los ua cov khoom carbon.
Kev npaj ntawm acid vlorides:Reacting di-tert-butyl dicarbonate nrog thentsyl chloride lossis oxalyl chloride loo cov ntaub aciding acid chlorides. Cov tshuaj chlorides acid yog cov reagents ntau yam siv nyob rau hauv ntau yam kev hloov pauv hluavtaws.
Khoom-theem peptide synthesis:Di-tert-butyl dicarbonate feem ntau yog siv nyob rau hauv kev tiv thaiv thiab cov kauj ruam tsis muaj nyiaj txaus hauv qib-theem peptide synthesis. Nws yog siv los tiv thaiv cov amino acids thaum lub sij hawm txuas ntxiv thiab tshem tawm cov pab pawg tiv thaiv kom ua rau cov amino pab cuam ntawm kev sib txuas ua ke.
Cov tshuaj tiv thaiv polymerization:Di-tert-butyl dicarbonate tuaj yeem ua tus tuav saw hloov mus rau cov neeg sawv cev polymerization. Nws tuaj yeem hnov cov roj polymer polymer, txiav lawv txoj kev loj hlob lossis tsim cov chaw tshiab reassive.
Cov no tsuas yog qee qhov piv txwv ntawm ntau cov ntawv thov ntawm di-tert-butyl dicarbonate hauv cov synthesis. Nws cov versatility thiab yooj yim ntawm kev siv ua nws ib qho khoom muaj nuj nqis nyob rau hauv ntau yam kev hloov pauv.
