Khoom
Dicyclohexylcarbodiimide; cas No.: 538-75-0
Txhais lus hais tias: DCCD; Dicyclohexylcarbodiimide
Kev Siv Khoom Ntawm Dicyclohexylcarbodiabide
Winds Ntag khaub ncaws / Xim: Tsis muaj xim
Art Vapor Siab: 1.044-1.15pa ntawm 20-25 ℃
● Melting point: 34-35 ° C (Lit.)
● Cov ntsiab lus tsis zoo: N20 / D 1.48
● Boaring taw tes: 277 ° C ntawm 760 MMHG
Flash taw tes: 113.1 ° C
● Psa:24.72000
Wensity: 1.06 g / cm3
● Cov cimp: 3.82570
● Cia Champ. :Ttore ntawm RT.
● Rhiab .:Moisture rhiab
● Solubility.:Methylene chloride: 0.1 g / ml, ntshiab, tsis muaj kob
● DEJ SOLUBILY.Kuv
● XlogP3: 4.7
It Hydrogen BRonor pub nyiaj: 0
● Hydrogen BR lees txais cov neeg lees paub: 2
Resot Rotatable Bond COUNTER: 2
● Muaj tseeb tseeb: 206.178298710
● Hnyav Hom Dav: 15
Complexity: 201
Luam Kev Thauj Khoom Dot: Tshuaj lom
Cov Ntaub Ntawv Safty
● POTOSSGRAM (S):
T,
Xn
● Cov cai phom sij: T, XN, T +
● Cov nqe lus: 23/24 / 25-34-43-41-36 / 38-24-24-22-62-37 / 38-10 / 22-20/8-20/11-20/38-20/2
● Cov nqe lus kev nyab xeeb: 26-36 / 39-49-41-24-37 / 39-24 / 25-36-16-53-28
Zoo siv
Tshuaj lom neeg:Nitrogen compound-> Lwm cov teb chaws nitrogen
Canonical luag nyav:C1cc (cc1) n = c = nc2cccccc2
Nqe lus piav qhia:Kev Kho Siab HeevSdohexyl Carboodiimide yog siv nyob rau hauv peptide requistry raws li coupling reagent. Nws yog ob qho tib si tsis sib xws thiab ua rau muaj kev tiv thaiv, thiab ua rau muaj kev hu rau hauv cov kws muag tshuaj thiab cov tshuaj tua kab mob.
Siv:Nyob rau hauv synthesis ntawm peptides. Cov khoom no feem ntau yog siv nyob rau hauv amikacin, glutathione dehydrants, nrog rau hauv synthesis ntawm acid anhydride, aldehyde, Ketone, Isocyanate; Thaum nws tau siv los ua cov neeg sawv cev ua kom lub cev qhuav dej, nws cuam tshuam rau Dicyclohexylrea los ntawm lub sijhawm luv luv raws li qhov kub. Cov khoom no tseem tuaj yeem siv hauv synthesis ntawm peptide thiab nucleic acid. Nws yog ib qho yooj yim siv cov khoom no kom hnov cov compound ntawm cov carboxy dawb thiab amino-pawg ua peptide. Cov khoom no tau siv dav hauv kev kho mob, kev noj qab haus huv, ua-tu thiab khoom siv tshuaj lom neeg, thiab lwm yam hluavtaws teb. N, n'-dicyclohexylcarbodiimide yog carboodiimide siv rau ob peb amino acids thaum lub sij hawm peptide synthesis. N, n'-dicyclohexylcarbodiimide yog siv los ua lub cev qhuav dej rau kev npaj ntawm kev npaj ntawm kev hloov pauv thiab eserification ntawm dej cawv ob. Dicyclohexylcarbodiimide yog siv los ua lub cev qhuav dej ntawm chav sov tom qab cov tshuaj tiv thaiv luv luv, tom qab cov tshuaj tiv thaiv khoom yog DICYCLOHEXYRUREA. Cov khoom yog cov solubility me me hauv cov organic huab cua, yog li ntawd yooj yim sib cais ntawm cov tshuaj tiv thaiv cov khoom.
Cov lus qhia ntxaws ntxaws
Dicyclohexylcarbodiimide (DCC) yog cov reagent ntau hauv cov organic synthesis. It is a white solid that is insoluble in water and soluble in organic solvents such as ethyl acetate and dichloromethane.
DCC yog feem ntau siv los ua cov neeg sawv cev hauv Peptide synthesis thiab lwm yam kev tawm tsam cuam tshuam nrog kev tsim ntawm kev sib raug zoo ntawm cov tsiaj ntawv. Nws txhawb nqa lub hws ntawm cov roj carboxylic nrog amines, coj mus rau qhov tsim ntawm cov chaw nyob. Nws ua tiav qhov no los ntawm kev ua kom cov carboxylic acid pab pawg thiab pab txhawb lub nucleophilic tawm ntawm cov amine ntawm cov carbonylol carbon.
Ntxiv rau peptide synthesis, DCC tseem siv rau ntau lwm cov organic, xws li Esterification thiab Kev Noj Khoom Haus. Nws tuaj yeem ua haujlwm rau cov ntawv Esters los ntawm carboxylic acids thiab dej cawv, thiab kom hloov cov tshuaj carboxylic acid, thiab ua kom anters) rau hauv cov chaw nyob.
DCC yog paub rau nws qhov kev ua haujlwm siab hauv kev txhawb nqa kev sib tw mus rau kev txhawb nqa kev sib raug zoo thiab rau nws txoj kev sib luag nrog ntau pawg ua haujlwm. Txawm li cas los xij, nws tseem pom zoo yog noo noo-rhiab thiab muaj peev xwm yooj yim decompose raws li kev sib txig. Yog li ntawd, nws yog feem ntau daws thiab khaws cia hauv qab ntawm kev mob phem.
Nws yog ib qho tseem ceeb uas yuav tsum tau ceev faj kev ceev faj thaum ua haujlwm nrog DCC, raws li nws tuaj yeem ua rau tawv nqaij, ob lub qhov muag, thiab ua pa. Qhov chaw dim pa thiab cov khoom tiv thaiv tus kheej yuav tsum siv thaum nws tuav.
Daim ntawv thov
Dicyclohexylcarbodiimide (DCC) pom ntau yam kev thov hauv cov khoom siv hauv siab hauv nruab nrog cev, tshwj xeeb hauv thaj teb ntawm Peptide Chemistry. Ntawm no yog ob peb cov ntawv thov tseem ceeb ntawm DCC:
Peptide synthesis:DCC yog feem ntau siv raws li kev sib txuas lus hauv peptide synthesis los koom cov amino acids ua ke thiab sau cov ntawv tso siab. Nws txhawb nqa cov kev cuam tshuam hws ntawm cov pab pawg carboxyl ntawm ib cov amino acid thiab cov amino pab pawg ntawm lwm tus, ua rau kev tsim cov peptide beptide.
Esterification cov kev tawm tsam:DCC tuaj yeem siv los hloov cov roj carboxylic acids nyob rau hauv estre los ntawm kev ua kom lawv muaj cawv. Nyob rau hauv lub xub ntiag ntawm DCC, carboxylic acid tau ua kom tau, pub nucleophilic tawm tsam los ntawm kev haus cawv los ua tus ester. Qhov tshuaj tiv thaiv no muaj txiaj ntsig zoo nyob rau hauv synthesis ntawm esters rau ntau yam kev siv.
Kev noj haus hais txog:DCC tuaj yeem pab txhawb kev ntsuas ntawm carboxylic acids, acid chlorides, kua qaub anhydrides, thiab ua kom zoo nkauj. Nws tso cai rau cov tshuaj tiv thaiv ntawm carboxylic acid derivative thiab ib qho amine los tsim ib qho kev sib cog lus rau txoj cai. Daim ntawv thov no pom cov nqi hluav taws xob hauv cov xwm txheej ntawm cov chaw nyob ntawm kev saib xyuas, uas tseem ceeb hauv ntau roj ntsha thiab tshuaj siv.
UGI REGOTION:DCC tuaj yeem siv tau hauv qhov kev tawm tsam Ugi, cov tshuaj tiv thaiv kab mob uas cuam tshuam nrog cov hws ntawm lub tsev kho hniav, ib qho isocyanide, carbonyl compound, thiab kua qaub. DCC tau pab ua kom cov carboxyl pab pawg ntawm cov kua qaub, tso cai rau kev hnov mob nrog cov amine thiab tsim ib qho kev sib cog lus rau kuv.
Khoom siv hluav taws xob:DCC feem ntau ua haujlwm hauv kev lag luam kws tshuaj rau kev sib tw ntawm cov neeg ua yeeb yam tshuaj thiab cov khoom xyaw muaj zog (API). Nws siv hauv peptide synthesis, thiab lwm yam kev hloov pauv tseem ceeb ua rau nws yog reagent nyob hauv kev tshuaj pom thiab kev txhim kho.
Nws tsim nyog sau cia uas DCC muaj ob peb lwm cov kev siv hauv cov hluavtaws muaj zog, suav nrog kev tsim cov uration, carbamates, thiab hydrazides. Nws cov vagatility thiab sib thooj nrog ntau pawg ua haujlwm ua rau nws muaj txiaj ntsig zoo cuab yeej hauv lub thawv tshuaj txiag.
