L-Malic acid

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Khoom npe:L-Malic acid

Synonyms:L-(-)-Malic acid, CP; Butanedioic acid, 2-hydroxy-, (2S)-; pinguosuan; Butanedioicacid, hydroxy-, (S)-; hydroxy-, (S)-Butanedioicacid; l-(ii) -malicacid, L-Gydroxybutanedioicacid, L-Mailcacid

CAS:97-67-6 : kuv

MF:C4H6O5

MW:134.09 Nws

EINECS:202-601-5

Khoom Categories:Cog Extracts; Aliphatics; MalicAcidSeries; Carboxylic Acids (Chiral); Chiral chemicals; Chiral Reagents; Khoom noj khoom haus & Pub ADDITIVES; Chiral Building Blocks; rau kev daws teeb meem ntawm Bases; Optical Resolution; Synthetic Organic Chemistry; Khoom noj khoom haus additives thiab acids ib 0001

Mol File:97-67-6. : kuv

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Product Detail

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Malic acid Chemical Properties

Melting point	101-103 ° C (lit.)
alpha	-2 º (c = 8.5, H2O)
Boiling point	167.16°C (kev kwv yees)
ceev	1.60 ib
vapor siab	0Pa ntawm 25 ℃
Refractive Index	-6.5 ° (C = 10, Acetone)
FEMA	2655 \|L-MALIC ACID
Fp	220 ° C
cia temp.	Khaws hauv qab +30 ° C.
solubility	H₂O: 0.5 M ntawm 20 ° C, ntshiab, tsis muaj xim
daim ntawv	Hmoov
xim	Dawb
Specific Gravity	1.595 (20/4 ℃)
PH	2.2 (10g / l, H2O, 20 ℃)
pka ua	(1) 3.46, (2) 5.10 (ntawm 25 ℃)
kev ua haujlwm kho qhov muag	[α] 20 / D 30 ± 2 °, c = 5.5% hauv pyridine
Dej Solubility	soluble
Merck	14, 5707 ib
JECFA Number	619 ib
BRN	1723541 ib
InChIKey	BJEPYKJPYRNKOW-REOHCLBHSA-N
LogP	-1.68
CAS DataBase Reference	97-67-6 (CAS DataBase Reference)
NIST Chemistry Reference	Butanedioic acid, hydroxy-, (s)-(97-67-6)
EPA Tshuaj Registry System	Butanedioic acid, 2-hydroxy-, (2S)- (97-67-6)

Cov ntaub ntawv kev nyab xeeb

Hazard Codes	Xi
Risk Statements	36/37/38 ib
Cov lus hais txog kev nyab xeeb	26-36-37/39 ib
WGK Germany	3
RTECS	TIAB SA 7175000
TSCA	Yog lawm
HS Code	29181980 ib

Malic acid Siv thiab Synthesis

Kev piav qhia	L-Malic acid yuav luag tsis muaj ntxhiab (qee zaum faint, acrid tsw) nrog tart, acidic saj.Nws yog nonpungent.Tej zaum yuav tau npaj los ntawm hydration ntawm maleic acid;los ntawm fermentation los ntawm qab zib.
Chemical Properties	L-Malic acid yog ze li ntawm tsis muaj ntxhiab (qee zaum faint, acrid tsw).Cov tshuaj no muaj ib tug tart, acidic, nonpungent saj.
Chemical Properties	clear colorless tov
Qhov tshwm sim	Nws tshwm sim hauv maple sap, kua, melon, papaya, npias, txiv hmab txiv ntoo, cocoa, sake, kiwifruit thiab chicory paus.
Siv	L-Malic acid yog siv los ua zaub mov ntxiv, Xaiv α-amino tiv thaiv reagent rau amino acid derivatives.Ntau yam synthon rau kev npaj cov tshuaj chiral suav nrog κ-opioid receptor agonists, 1α,25-dihydroxyvitamin D3 analogue, thiab phoslactomycin B.
Siv	Qhov tshwm sim ntawm isomer yog L-daim ntawv uas tau pom nyob rau hauv txiv apples thiab ntau lwm txiv hmab txiv ntoo thiab nroj tsuag.Xaiv α-amino tiv thaiv reagent rau amino acid derivatives.Ntau yam synthon rau kev npaj ntawm chiral compounds nrog rau κ-opioid rece
Siv	Intermediate hauv chemical synthesis.Chelating thiab buffering tus neeg sawv cev.Flavoring agent, tsw enhancer thiab acidulant nyob rau hauv cov khoom noj.
Txhais	ChEBI: Ib daim ntawv kho qhov muag ntawm malic acid muaj (S)-kev teeb tsa.
Kev npaj	L-Malic acid tuaj yeem npaj los ntawm hydration ntawm maleic acid;los ntawm fermentation los ntawm qab zib.
Kev piav qhia dav dav	L-Malic acid yog cov organic acid uas feem ntau pom nyob rau hauv cawv.Nws plays lub luag haujlwm tseem ceeb hauv cawv microbiological stability.
Biochem/physiol Actions	L-Malic acid yog ib feem ntawm cellular metabolism.Nws daim ntawv thov raug lees paub hauv kws tshuaj.Nws muaj txiaj ntsig zoo hauv kev kho mob hepatic malfunctioning, zoo tiv thaiv hyper-ammonemia.Nws yog siv los ua ib feem ntawm cov amino acid infusion.L-Malic acid kuj ua hauj lwm raws li ib tug nanomedicine nyob rau hauv kev kho mob ntawm lub paj hlwb neurological ntshawv siab.TCA (Krebs cycle) nruab nrab thiab tus khub hauv malic acid aspartate shuttle.
Txoj kev Purification	Crystallize S-malic acid (charcoal) los ntawm ethyl acetate / tsiaj ether (b 55-56o), ua kom kub hauv qab 65o.Los yog yaj nws los ntawm refluxing nyob rau hauv kaum tsib qhov chaw ntawm anhydrous diethyl ether, decant, mloog zoo rau ib feem peb ntim thiab crystallize nws ntawm 0o, dua mus tas li melting point.[Beilstein 3 IV 1123.]