Khoom
Methyl D - (-) - 4-hydroxy-phenylglycinate; CAS A.: 37763-23-8
Cov lus txhais: benenzerrasacid, α-amino-4-hydrothphenyf) glycine; dp-hydroxyphenylglycine methyl ester; methyl eser; methyl D - (-) - α-amino-amino-α- (4-hydroxyphenyc) acetate; methyl (r) -Aminofyl) acetate;
Cov Khoom Siv Tshuaj Txhuam Me Me D - (-) - 4-Hydroxy-Phenyylglycate
Vapor siab: 6.03e-05mmHG ntawm 25 ° C
● Cov ntsiab lus tsis zoo: 1.57
● Bowing taw tes: 335.7 ° C ntawm 760 MMHG
● PKA: 9.74 ± 0.26 (kwv yees)
Flash taw tes: 156.9 ° C
● PSA: 72.55000000000
Wensity: 1.248 g / cm3
● Cov cim: 1.26530
● Chaw Cia Khoom Ntim
● Solubility.:Dmo (me ntsis), ethanol (me ntsis, sonicated), methanol (me ntsis)
● Xlog3: 0.5
Hydrogen BRonor Pub pub Suav: 2
Hydrogen BRRong tau txais kev lees paub: 4
Resot Rotatable Bond cee: 3
● Muaj tseeb tiag tshua: 181.07389321
● Hnov Cov Atom Nruab Nrab hnyav: 13
Comllexity: 176
Cov Ntaub Ntawv Safty
● POTOSSGRAM (S):
● Cov kab mob txaus ntshai:
Zoo siv
● Ciaj Nrauj Smiles: Coc (= O) C (C1 = CC = C (C = C1) O) N
● Siv cov methyl d - (-) - hydroxy-phenylglycinate muaj txiaj ntsig rau cov synthesis (+) - radicamine B. Tsis tas li, nws yog siv rau kev npaj ntawm Amoxicillin.
Cov lus qhia ntxaws ntxaws
D-4-hydroxyphenylglycly Methyl Ester, tseem hu ua D-HPG Methyl Ester thiab D-4-hydroyl esyl esyloride, yog cov tshuaj muttersylgly3 thiab cov pob txha mos ntawm 181.19 g / mol. Nws yog methyl ester daim ntawv ntawm d-4-hydroxyphenylglycine.d-4-hydroylestylglycine astyl ester yog suav cov nplhaib phenyl Nws tau raug synthesized rau ntau cov ntawv thov, suav nrog nws cov kev siv ua lub tsev muaj cov tshuaj synthesclyclysclycly methyl ester yog nws txoj kev koom tes hauv synthesis ntawm cov tshuaj. Nws tuaj yeem ua haujlwm ua ntej kev tsim cov tshuaj xws li β-lactam tshuaj tua kab mob, peptide analogs, thiab lwm cov tebchaw bioaction. Nws teeb tsa rau hauv cov tshuaj ntawm cov tshuaj no tuaj yeem qhia lawv cov haujlwm.Furthermore, d-4-hydrothylest pom cov peev txheej ntawm nws tus kheej. Nws tau kawm rau nws cov antioxidant, anti-inflampatory, thiab neuroprotecting cuam tshuam. Cov khoom no ua rau nws muaj kev txaus siab rau kev txhim kho cov tshuaj rau ntau yam tshuaj mob methylasclycly, suav nrog cov tshuaj lom neeg metylas, suav nrog cov tshuaj lom neeg metylgly Nws cov qauv tshwj xeeb thiab cov nkauj chiral ua rau nws muaj txiaj ntsig zoo li lub tsev tsim kev tsim tshuaj, thiab nws cov kev ua kom pom kev ua haujlwm kom nws muaj peev xwm rau ntau daim ntawv thov kho mob.
Daim ntawv thov
Methyl D - (-) - 4-hydroxy-phenylglycinate muaj ntau lub peev xwm siv thiab cov ntawv thov:
Kev Tshawb Fawb Txog Kev Tshawb Fawb:Cov compound no tuaj yeem raug siv los ua lub tsev thaiv hauv cov hluavtaws ntawm ntau yam khoom sib xyaw. Nws ua haujlwm nruab nrab rau cov hluavtaws ntawm cov tshuaj thiab cov kev nquag ua haujlwm sib txuas.
Chairal daws teeb meem:Cov compound lub chairality ua rau nws muaj txiaj ntsig rau kev tshawb fawb txog chairal daws teeb meem. Nws tuaj yeem siv los cais cov rapemic sib tov rau hauv lawv cov neeg enantiomers.
Asymmetric synthesis:Methyl D - (-) - 4-hydroylglycinate tuaj yeem siv raws li chairal ib qho synthesis, ua kom cov synthesis ntawm cov kev sib txuas ua ke.
Kev Tsim Tshuaj Yeeb:Cov qauv sib xyaw thiab cov khoom ua rau nws muaj peev xwm sib tw rau kev tsim tshuaj ntsuab.Nov tuaj yeem hloov kho nws cov tshuaj zoo li cov khoom siv tshuaj-zoo li.
Nws yog qhov tseem ceeb kom nco ntsoov tias cov nqi hluav taws xob tshwj xeeb ntawm methyl d - (- 4-hydroxy-phenylglycate yuav nyob ntawm cov kev tshawb fawb xav tau lossis kev sab laj nrog cov kws tshaj lij yuav tsim nyog.
